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Imine reductase (IRED)
E uiga ile Imine reductase
ES-IRED: O se vasega o enzymes e faʻamalosia le faʻaititia o le C=N faʻamau i le CN bond.E a'afia i le redox enzyme, ma le coenzyme NADPH mo le felauaiga o le hydrogen.E tusa ai ma le manaʻoga sili o oloa, e mafai ona vaevaeina i R-IRED ma S-IRED.Syncozymes atiina ae 15 imine reductases (numbIRED ES-IRED-101-ES-IRED-115), lea e mafai ona faaaoga lautele i regioselective ma stereoselective faaitiitia o imines e saunia chiral amines.
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Nitrile reductase (NRED)
E uiga i le Nitrile reductase
E 3 ituaiga NRED enzyme oloa (Numera pei ES-NRED101~ ES-NRED103) atiaʻe e SyncoZymes.E mafai e le NRED ona faʻamalosia le faʻaitiitia o le vaega nitrile i amine.I le faagasologa o le catalysis, e manaʻomia le NADPH e avea ma felauaiga hydrogen.
Nitrile reductasecatalytic reaction type
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Phenylalanine dehydrogenase (PDH)
E uiga i le Phenylalanine dehydrogenase
ES-PDH: O se vasega o le oxidoreductase.O le tali lelei e mafai ona faʻamalosia ai le faʻamaʻiina o le masima L phenylalanine i luma o le NAD e maua ai le masima phenylpyruvate, ma o le faʻafeagai faʻafefe e mafai ona faʻapipiʻiina le faʻaogaina o masima amino acid tutusa mai masima phenylpyruvate.Na fausia e Syncozymes mea e 8 o le phenylalanine dehydrogenase (faanumera ES-PDH-101~ES-PDH-108).E mafai ona fa'aoga le ES-PDH e saunia ai le masima phenylalanine po'o le masima amino acid tutusa mai masima phenylpyruvic acid po'o mea e maua mai.
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Leucine Dehydrogenase (LeuDH)
E uiga i le Leucine dehydrogenase
E 1 le ituaiga o oloa enzyme LeuDH (Numera e pei o le ES-LeuDH-101) na atiaʻe e SyncoZymes.LeuDH e mafai ona faʻamalosia le faʻaitiitia o le ammoniation o le 4-methylbutanoic acid (masima) i le L-leucine poʻo le faʻamaʻiina o le leucine i le 4-methylbutanoic acid.E mafai foi e le ES-LeuDH ona faʻapipiʻiina le faʻaitiitia o le amination o le α-keto acids faʻatasi ai ma le fausaga tutusa e saunia ai mea e maua mai i le amino acid.I le faagasologa o le catalysis, e manaʻomia le NADH e pei o le hydrogen transporter.
Leucine dehydrogenasecatalytic reaction type
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Threonine deaminase (TDA)
E uiga i le Threonine deaminase
ES-TDA (Threonine deaminase): o se porotini pyridoxal phosphate e faʻamalosia le deamination o le threonine e maua ai le 2-ketobutyric acid ma le ammonia.Pyridoxal 5-phosphate e manaʻomia e fai ma coenzyme i le faʻaogaina o le faʻaogaina.E na'o le tasi le ituaiga TDA enzyme product (Numera e pei o le ES-TDA) na atia'e e SyncoZymes, lea e mafai ona fa'aoga e saunia ai le 2-ketobutyric acid po'o ona mea e maua mai i le threonine.
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Amine Dehydrogenase (AmDH)
E uiga i le Amine Dehydrogenase
ES-AmDH (Amine Dehydrogenase): o se enzyme e mafai ona faʻamalosia le ammoniation o le carbonyl group ma faʻaititia i le vaega amino.O se enzyme fa'alagolago i le NADH coenzyme, ma o le NADH o lo'o galue e pei o se fa'aliliuga hydrogen.E 4 ituaiga o oloa enzyme AmDH (Numera pei ES-AmDH101～ES-AmDH104) atiaʻe e SyncoZymes, lea e mafai ona faʻaaogaina i le regioselective poʻo le stereoselective reductive amination o aldehydes ma ketones.
Ituaiga tali fa'amamafa:
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Nucloside phosphoryalse (NP)
E uiga i le nucleoside phosphoryalse
E 3 ituaiga o oloa enzyme NP (Numera pei ES-NP-101~ ES-NP-103) atiaʻe e SyncoZymes.ES-NP-101 o le purine nucleoside phosphorylase, ES-NP-102 ma le ES-NP-103 o le pyrimidine nucleoside phosphorylase.Nucleosidephosphorylase e mafai ona pala le nucleosides i faavae ma pentose phosphate.Nucleoside phosphorylase e mafai ona vaevaeina i le purine nucleoside phosphorylase ma le pyrimidine nucleoside phosphorylase e tusa ai ma le manaʻoga o faʻavae nucleoside.O le purine nucleoside phosphorylase e mafai ona faʻaaogaina le adenosine i le adenine, inosine i le hypoxanthine, guanosine i le guanine, ma maua ai le ribose phosphate i le taimi e tasi.Pyrimidine nucleoside phosphorylase e mafai ona faʻafefete uridine i le uracil ma maua ai le ribose phosphate.
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Hydroaminase (HAM)
E uiga i le Hydroaminase
E 2 ituaiga o oloa enzyme HAM (Numera e pei ES-HAM-101~ ES-HAM-102) atiaʻe e SyncoZymes.E mafai e le HAM ona fa'atupuina le ammoniation o le enoic acid po'o ona mea e maua mai ai le chiral amino acids.E mafai ona fa'aogaina le HAM e fa'atupu ai le chiral amino acids (po'o chiral amines) mai enoic acids (po'o alkenes).Ammonia foaʻi, e pei o le vai ammonia poʻo le masima ammonium, e manaʻomia.
Hydroaminase catalytic ituaiga tali
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Ua le mafai ona gaoioi CALB
CALB
Recombinant Lipase B mai le Candida antarctica (CALB) e gaosia e ala i le fa'apa'ele'ele i le vai fa'atasi ma Pichia pastoris.
CALB e mafai ona faʻaaogaina i le vai poʻo le vaega faʻaletino catalytic esterification, esterolysis, transesterification, mama tatala polyester synthesis, aminolysis, hydrolysis o amides, acylation o amines ma tali faaopoopo.
CALB o loʻo i ai le maualuga o le filifilia o le chiral ma le filifilia o le tulaga, o lea e mafai ai ona faʻaaogaina lautele i le gaosiga o suauʻu, meaʻai, vailaʻau, mea teuteu ma isi vailaʻau vailaʻau.
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NADH oxidase (NOX)
E uiga ile NADH oxidase
ES-NOX (NADH oxidase): NOX faʻamalosia le faʻamaʻiina o le NADH i le NAD +, ma o le oxidoreductase.I le faagasologa o le faʻamaʻiina, o le O2 e manaʻomia e pei o le oxidant, ma faʻaititia i le H2O poʻo le H2O2.E 4 ituaiga o oloa enzyme NOX (ES-NOX-101 ~ ES-NOX-104) atiaʻe e la matou kamupani, lea e mafai ona faʻaaogaina mo le toe faʻafouina o le coenzyme NAD +.
Ituaiga tali fa'amamafa:
or
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Phenylalanine ammonia lyase (PAL)
E uiga i le Phenylalanine ammonia lyase
ES-PAL: O se vasega o enzymes e fa'apipi'iina le fa'a'esea sa'o o le L-phenylalanine i le transcinnamic acid.Na fausia e Syncozymes mea e 10 o le phenylalanine ammonia lyase (numera ES-PAL-101~ES-PAL-110), lea e mafai ona faʻaaogaina i le deamination poʻo le faʻafefe o le phenylalanine ma ona mea e maua mai ai.
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Catalase (CAT)
E uiga ia Catalase
ES-CAT (Catalase): fa'apipi'i le pala o le H2O2 ile okesene ma le vai.E masani lava ona i ai i le mitochondria, endoplasmic reticulum, ate manu ma sela mumu toto, aemaise lava ile ate ile maualuga maualuga, e maua ai le puipuiga o le antioxidant mo le tino.I le biocatalysis, e masani ona faʻaaogaina e aveese ai le faʻaogaina o le hydrogen peroxide ma faʻaitiitia ai le faʻasaina ma le le faʻaaogaina o le enzyme e le hydrogen peroxide.E na'o le tasi le ituaiga CAT enzyme products atia'e e SyncoZymes (Numera pei ES-CAT).
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