Amine Dehydrogenase (AmDH)
Fa'amatalaga Puupuu:
E uiga i le Amine Dehydrogenase
ES-AmDH (Amine Dehydrogenase): o se enzyme e mafai ona faʻamalosia le ammoniation o le carbonyl group ma faʻaititia i le vaega amino.O se enzyme fa'alagolago i le NADH coenzyme, ma o le NADH o lo'o galue e pei o se fa'aliliuga hydrogen.E 4 ituaiga o oloa enzyme AmDH (Numera pei ES-AmDH101～ES-AmDH104) atiaʻe e SyncoZymes, lea e mafai ona faʻaaogaina i le regioselective poʻo le stereoselective reductive amination o aldehydes ma ketones.
Ituaiga tali fa'amamafa:
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I-Meli:lchen@syncozymes.com
★ maualuga substrate specificity.
★ Malosi le filifilia o chiral.
★ Liliu maualuga.
★ Faʻaitiitia mea faʻatau.
★ Tulaga tali malie.
★ Siosiomaga.
➢ E masani lava, o le faiga e tali atu ai e tatau ona aofia ai le mea'ai, vaifofo pa'u, enzyme, coenzyme ma le coenzyme regeneration system (fa'ata'ita'iga o le kulukose ma le glucose dehydrogenase).
➢ E tatau ona fa'aopoopo mulimuli le AmDH i le faiga fa'afoliga, pe a uma ona fetu'una'i le pH ma le vevela i le tulaga e tali atu ai.
Fa'ata'ita'iga 1(Fa'amaopoopoina o amine chiral tutusa e ala i le fa'amination fa'aitiitia o alkyl aryl ketones)(1):
Taofi le 2 tausaga i lalo -20℃.
Aua ne'i fa'afeso'ota'i i tulaga ogaoga e pei o le: maualuga le vevela, maualuga/maualalo le pH ma le maualuga o le fa'aogaina o so'o.
1. Kong W, Liu Y, Huang C, et al.Angewandte Chemie Lomiga Faavaomalo, 2022: e202202264.
