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Transaldolase (TAL)
E uiga i le Transaldolase
ES-TAL (Transaldolase): e faasino tele lava i threonine transaldolases, lea e mafai ona fa'agaoioia le tali atu e fa'aputu ai β-hydroxyphenylalanine derivatives fa'atasi ai ma threonine ma benzaldehyde derivatives. O le TAL o se enzyme e fa'alagolago i le PLP. E na'o le tasi le ituaiga o oloa o le enzyme TAL (Numera o le ES-TAL101) na atia'e e SyncoZymes, lea e mafai ona fa'aaogaina e fa'aputu ai le β-hydroxyphenylalanine ma ona derivatives.
Ituaiga o tali fa'a-catalytic:
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Imeli:lchen@syncozymes.com
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Ketoreductase (KRED)
E uiga i le Ketoreductase
Enzymes: O ni macromolecular biological catalysts, o le tele o enzymes o porotini.
Ketoreductase: E ta'ua fo'i o le "Carbonyl reductase", o ni enzymes e fa'atino ai le reversible redox reaction i le va o aldehydes / ketones ma alcohols, ma e mana'omia ni coenzymes e fai ma H transmitter e pei o le NADH po'o le NADPH. E tolu vaega autū o le KRED: Short-chain Dehydrogenase / Reductases (SDRs), Medium-chain Dehydrogenases / Reductases (MDRs), ma Aldo-KetoReductases (AKRs). E tutusa galuega fa'atino a nei mea e tolu, ae e matua'i eseese lava le fausaga ma meatotino.
Telefoni feavea'i/Wechat/WhatsApp: +86-13681683526
Imeli:lchen@syncozymes.com
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Transaminase (ATA)
E uiga i le transaminase
ATA mai SyncoZymes: E 66 ituaiga oloa o le enzyme ATA (Numera o le ES-ATA-101~ES-ATA-166) na atiae e SyncoZymes. O le SZ-ATA o se meafaigaluega aoga e fa'agaoioia ai le regio- ma le stereoselective synthesis o chiral amines, amino acids ma a latou mea e maua mai i le tele o aliphatic ma aromatic ketoacids, aldehydes, ketones ma ketoses.
Telefoni feavea'i/Wechat/WhatsApp: +86-13681683526
Imeli:lchen@syncozymes.com
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Nitrilase (NIT)
E uiga i le Nitrilase
ES-NITs: Liliu sa'o le vaega cyanide i le vaega carboxyl, e saunia ai le carboxylic acid, lea e fa'aaogaina lautele i vaila'au, puipuiga o le siosiomaga, alamanuia o vaila'au, fa'aopoopoga mea'ai, ie, gaosiga fa'ato'aga ma isi matā'upu.
E 40 ituaiga o oloa Nitrilase(NIT) (Numera o le ES-NIT-101~ES-NIT-140) na atiae e SyncoZymes. O le ES-NIT o se meafaigaluega aoga e fa'agaoioia ai le fa'aputuina o chiral carboxylic acids e ala i le regio- ma le stereoselective hydrolysis o le tele o aliphatic ma aromatic nitriles.Ituaiga o tali fa'a-catalytic:
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Imeli:lchen@syncozymes.com
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Nitrile hydratase (NHT)
E uiga i ES-NHTs
ES-NHTs: o se vasega o metalloenzyme, lea e fa'asusu fa'apitoa ai nitriles i totonu o le amide autu talafeagai. E fa'aaogaina lautele e le gata mo le fa'aputuina o amino acids, amides, carboxylic acids ma a latou mea e maua mai ai, ae fa'apea fo'i mo le sauniaina o vaila'au chiral. E 24 ituaiga o nitrile hydratases na atia'e e SyncoZymes (Numera o le ES-NHT-101～ES-NHT-124).
Ituaiga o tali fa'a-catalytic:
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Imeli:lchen@syncozymes.com
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Amidase (AMD)
AMD mai SyncoZymes: E 19 ituaiga o oloa enzyme AMD (Numera o le ES-AMD-101~ES-AMD-119) na atiae e SyncoZymes. O le SZ-AMD o se meafaigaluega aoga e fa'agaoioia ai le regio- ma le stereoselective synthesis o chiral carboxylic acids ma a latou mea e maua mai i le tele o aliphatic ma aromatic amides.
Telefoni feavea'i/Wechat/WhatsApp: +86-13681683526
Imeli:lchen@syncozymes.com
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Ene reductase (ERED)
E uiga i le ene reductase
ES-EREDs: E aofia i le aiga o enzymes samasama tuai e fa'aitiitia fa'apitoa le C=C i totonu o α, β-unsaturated compounds fa'atasi ai ma vaega e mitiia ai le eletise. E fa'aaogaina lautele i le su'esu'eina o amino acid derivatives, bioactive substances, pharmaceutical intermediates, spices and chiral blocks.
Telefoni feavea'i/Wechat/WhatsApp: +86-13681683526
Imeli:lchen@syncozymes.com
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Oxynitrilases (HNL)
E uiga i oxynitrilases
ES-HNLs: O se vasega enzyme e fa'agaoioia ai le fa'aopoopoina o le HCN i aldehydes (ketones) e maua ai le R po'o le S ituaiga cyanide alcohols, lea e faigofie ona liua i le tele o ituaiga o vaila'au po'o vaila'au fa'asaina e ala i le metotia fa'akemikolo.
E 29 ituaiga o oloa oxynitrilase (Numera o le ES-HNL-101～ES-HNL-129) na atiae e SyncoZymes. O le SZ-HNL o se meafaigaluega aoga mo le regio- ma le stereo-selective synthesis o le (R)-cyanohydrins po'o le (S)-cyanohydrins mai le tele o aromatic, aliphatic ma heterocyclic aldehydes po'o ketones fo'i.
Ituaiga o tali fa'a-catalytic:
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Imeli:lchen@syncozymes.com
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Nitro reductase (NTR)
E uiga i le nitro reductase
ES-NTRs: O flavoenzymes ia e fa'atino ai le fa'aitiitia o vaega nitro e fa'alagolago i le NAD(P)H i luga o nitroaromatic ma nitroheterocyclic compounds i hydroxylamino ma/po'o amino derivatives. E fa'aaogaina lautele i le fa'aputuga fa'alenatura o le aromatic hydroxylamine ma le aromatic amine, togafitiga o le tumo, iloa o meaola ma le fa'aleagaina o mea leaga o le siosiomaga. E 12 ituaiga o oloa Nitro reductase (NTR) (Numera o le ES-NTR-101~ES-NTR-112) na atia'e e SyncoZymes.
Telefoni feavea'i/Wechat/WhatsApp: +86-13681683526
Imeli:lchen@syncozymes.com
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Aldolase (DERA)
ES-DERAs: E mafai ona fa'atino lelei le fa'aopoopoga fa'apitoa o ketones foa'i i aldehydes receptor. E le gata i lea, e mafai ona fa'atinoina le tali i totonu o le vai o le pH neutral e aunoa ma ni puipuiga fa'apitoa. E aofia i latou i le vasega I aldolase, lea e fausia ai le Shiff base i le fa'agasologa fa'asolosolo. O le substrate e feso'ota'i fa'atasi ma le amino group o le active site e amata ai le motusia ma le fausiaina o le fusi. O le eseesega i le va o DERAs ma isi aldolases o substrates latou te fa'atino o aldehydes ma e mafai ona fa'aauau pea le fa'aputuina o aldehydes.
Telefoni feavea'i/Wechat/WhatsApp: +86-13681683526
Imeli:lchen@syncozymes.com
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Cytochrome P450 monooxygenase (CYP)
E uiga i le CYP
ES-CYPs: O se vasega o enzymes redox ma le mercaptan-heme o le totonugalemu galue e fa'agaoioia ai le fesiitaiga o le okesene. O ni oxygenases fa'ai'u ma e mana'omia le heme e fa'agaoioia ai le okesene.
E fa'atino e le Cytochrome P450 monooxygenase le fa'a'okeseneina, epoxidation ma le hydroxylation o le alkyl, hydroxylation ma le fa'a'okeseneina o le ammonia, fa'a'okeseneina o le sulfur, dealkylation (oxygen, sulfur, ammonia), oxidative dehydrogenation, deamination ma le dehalogenation.
E 8 ituaiga o oloa o le cytochrome P450 monooxygenase (Numera o le ES-CYP-101～ES-CYP-108) na atia'e e SyncoZymes.Telefoni feavea'i/Wechat/WhatsApp: +86-13681683526
Imeli:lchen@syncozymes.com
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Okisase o le ava malosi (AOX)
E uiga i le ava malosi oxidase
ES-AOXs: E mafai e nei enzymes ona fa'agaoioia le oxidation o ga'o alcohols po'o aryl-alcohols e fausia ai aldehydes. Latou te fa'aaogaina le molecular oxygen ae le mana'omia se cofactor fa'aopoopo mai fafo, ma le hydrogen peroxide e gaosia.
E 6 ituaiga o oloa o le alcohol oxidases (Numera o le ES-AOX-101~ES-AOX-106) na atiae e SyncoZymes. E fiafia le ES-AOX101 ma le ES-AOX102 i mea e fa'aaoga ai le aliphatic alcohol substrates, e fiafia le ES-AOX103~ES-AOX105 i mea e fa'aaoga ai le aromatic alcohol substrates, ma le ES-AOX106 o le cholesterol oxidase. O le SZ-AOX o se meafaigaluega aoga e fa'agaoioia ai le oxidation o fatty alcohols po'o aryl-alcohols e gaosia ai aldehydes.
Ituaiga o tali fa'a-catalytic:
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Imeli:lchen@syncozymes.com
