O le Clenbuterol, o se β2-adrenergic agonist (β2-adrenergic agonist), e tutusa ma le ephedrine (Ephedrine), e masani ona faʻaaogaina i togafitiga faafomaʻi e togafitia ai le faʻamaʻi pipisi o le mama (COPD), e faʻaaogaina foʻi o se bronchodilator e faʻaitiitia ai le faʻateleina o le tale. I le amataga o le 1980, na iloa faʻafuaseʻi e le kamupani Amerika Cyanamid o loʻo i ai ni aafiaga manino o le faʻaleleia atili o le tuputupu aʻe, faʻaleleia atili le fua o aano o manu ma faʻaitiitia le gaʻo, o lea na faʻaaogaina ai o se clenbuterol i le faʻatoʻaga manu. Peitaʻi, ona o ona aafiaga i itu, na faʻasaina ai e le European Community le faʻaaogaina o le clenbuterol o se mea faʻaopoopo i meaʻai talu mai Ianuari 1, 1988. Na faʻasaina e le FDA i le 1991. I le 1997, na faʻasaina malosi ai e le Matagaluega o Faʻatoʻaga a le People's Republic of China le faʻaaogaina o hormones beta-adrenergic i le gaosiga o meaʻai ma faʻatoʻaga manu, ma o le Clenbuterol hydrochloride na tulaga muamua.
Peita'i, ua fa'aalia talu ai nei e mafai e le racemic Clenbuterol ona fa'aitiitia le lamatiaga o le fa'ama'i o Parkinson. Ina ia fa'amaonia po'o fea (pe o itu uma e lua) isomers e mafua ai lenei aafiaga, e mana'omia ona su'esu'eina eseese le Clenbuterol enantiomer mama.
I se tusiga talu ai nei, o le vaega suʻesuʻe a Elisabeth Egholm Jacobsen o le Matagaluega o Kemisi, le Iunivesite o Saienisi ma Tekonolosi a Nouei, faatasi ai ma Dr. Zhu Wei o Shangke Bio, na faʻatinoina le faʻagasologa o le ketoreductase KRED ma le cofactor nicotinamide adenine dinucleoside phosphate (NADPH). (R)-1-(4-Amino-3,5-dichlorophenyl)-2-bromoethan-1-ol, ee > 93%; ma le (S)-N-(2 na faʻatinoina e le faiga lava lea e tasi, 6-Dichloro-4-(1-hydroxyethyl)phenyl)acetamide, ee >98%. O mea uma e lua o loʻo taʻua i luga o ni mea e ono avea ma precursors o clenbuterol isomers. O le ketoreductase ES-KRED-228 na faʻaaogaina i lenei suʻesuʻega na sau mai le Shangke Biopharmaceutical (Shanghai) Co., Ltd. O le iʻuga o le suʻesuʻega "Chemoenzymatic Synthesis of Synthons as Precursors for Enantiopure Clenbuterol and Other -2-Agonists" na lomia i le "Catalysts" ia Novema 4, 2018.
Taimi na lafoina ai: Aokuso-26-2022