SyncoZymes

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Suʻesuʻega alualu i luma i luga o le enzymatic faʻapipiʻi o mea e mafai ona faʻatupuina o le Clenbuterol i le galulue faʻatasi i le va o Norwegian Iunivesite o Saienisi ma Tekinolosi ma Shangke Biomedical

Clenbuterol, o se β2-adrenergic agonist (β2-adrenergic agonist), e tutusa ma le ephedrine (Ephedrine), e masani ona faʻaaogaina ile falemaʻi e togafitia ai faʻamaʻi faʻamaʻi faʻamaʻi faʻamaʻi (COPD), E faʻaaogaina foi e avea o se bronchodilator e faʻamalolo ai faʻamaʻi ogaoga o le sela.I le amataga o le 1980s, na faʻafuaseʻi ona iloa e le kamupani Amerika Cyanamid o loʻo i ai aʻafiaga manino o le faʻaleleia o le tuputupu aʻe, faʻaleleia le fua o aano o manufasi ma faʻaitiitia le gaʻo, o lea na faʻaaogaina ai le clenbuterol i le fagafao manu.Ae ui i lea, ona o ona aʻafiaga, na faʻasaina ai e le European Community le faʻaaogaina o le clenbuterol e avea o se meaʻai faaopoopo talu mai Ianuari 1, 1988. Na faʻasaina e le FDA i le 1991. I le 1997, na matua faʻasaina e le Matagaluega o Faatoaga a le Malo o Saina. le faʻaogaina o hormones beta-adrenergic i meaʻai ma le gaosiga o manu, ma Clenbuterol hydrochloride tulaga muamua.

Ae ui i lea, racemic Clenbuterol talu ai nei na faʻaalia e faʻaitiitia ai le lamatiaga o le maʻi o Parkinson.Ina ia faʻamaonia poʻo fea (poʻo uma) isomers e maua ai lenei aafiaga, o le Clenbuterol enantiomer mama e tatau ona suʻesuʻeina eseese.

I se tala talu ai nei, o le vaega suʻesuʻe a Elisabeth Egholm Jacobsen o le Matagaluega o Chemistry, Norwegian Iunivesite o Saienisi ma Tekinolosi, i le galulue faatasi ma Dr. Zhu Wei o Shangke Bio, catalyzed le synthesis o le ketoreductase KRED ma cofactor nicotinamide adenine dinucleoside phosphate (NADPH). ).(R)-1-(4-Amino-3,5-dichlorophenyl)-2-bromoethan-1-ol, ee > 93%;ma le (S)-N-(2 na fa'apipi'iina e le faiga lava lea e tasi,6-Dichloro-4-(1-hydroxyethyl)phenyl)acetamide, ee>98%.O mea e lua o loʻo taʻua i luga e mafai ona avea ma mea muamua o isomers clenbuterol.O le ketoreductase ES-KRED-228 na faʻaaogaina i lenei suʻesuʻega na sau mai le Shangke Biopharmaceutical (Shanghai) Co., Ltd. O le suʻesuʻega o le "Chemoenzymatic Synthesis of Synthons as Precursors for Enantiopure Clenbuterol and Other -2-Agonists" na lomia i le "Catalysts" i luga Novema 4, 2018.

Su'esu'ega aga'i i luma ile fa'aogaina ole enzymatic

Taimi meli: Aukuso-26-2022